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Light and Electron Microscopic Retinal Findings in Leigh's Disease

 

作者: I. Kremer,   T. Lerman-Sagie,   M. Mukamel,   J. Sandbank,   I. Nissenkorn,   M. Mimouni,  

 

期刊: Ophthalmologica  （Karger Available online 1989）
卷期: Volume 199, issue 2-3  

页码: 106-110

 

ISSN:0030-3755

 

年代: 1989

 

DOI:10.1159/000310025

 

出版商: S. Karger AG

 

关键词: Mitochondrial disorders;Epiretinal membrane;Large macrophages;Degenerated mitochondria

 

数据来源: Karger

 

摘要:

Funduscopic and retinal light- and electron-microscopic findings are described in an infant with progressive neurologic deterioration leading to death. Brain autopsy findings were consistent with Leigh’s disease. The retinal mitochondria showed marked degenerative changes, the cristae were almost completely destroyed and electron-dense material filled a major part of the cavity. These changes are typically described in the late stages of mitochondrial diseases but have not been described before in retinal mitochondria in a patient with Leigh’s disease.

 

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