Penetration of Clindamycin into Bone in Man
作者:
V. Vacek,
M. Hejzlar,
M. Slavík,
R. Pavlanský,
期刊:
Chemotherapy
(Karger Available online 1972)
卷期:
Volume 17,
issue 1
页码: 22-25
ISSN:0009-3157
年代: 1972
DOI:10.1159/000220835
出版商: S. Karger AG
关键词: Pharmacokinetics;Clindamycin;Tissue concentration;Serum concentration
数据来源: Karger
摘要:
Clindamycin (7-chloro-7-deoxylincomycin-hydrochloride-monohydrate) is an antibiotic with a remarkable bacteriostatic and bactericidal activity against staphylococci [1, 4, 5, 8]. It may, therefore, be regarded as one of the drugs suited for therapy of staphylococcal osteomyelitis, especially after very good efficacy of Lincomycin was recorded in this disease. To confirm this assumption, however, the data on penetration of Clindamycin into the bone under conditions of routine clinical practice are needed above all. This study presents the preliminary results obtained in this respect.
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