The past year has seen many developments in our understanding of the clinical patterns of genital herpes, including asymptomatic carriage and transmission. These issues raise concerns about transmission and contribute significantly to the psychosocial impact of this disease. Management strategies are rapidly changing as we enter the era of possible vaccine intervention. Management during pregnancy continues to raise controversies, stimulating the Infectious Diseases Society of America to publish official recommendations. New data, however, show us that health care providers are doing a relatively poor job of giving appropriate care and emotional support to patients in need. Similarly, human papilloma virus infections can also be missed on a clinical basis. Infection may be multifocal nature and even oral. Psychosocial impact can be severe with this incurable virus. Its correlation with cervical and vulvar neoplasia becomes more evident, while management strategies address only the majority of clinical warts leaving much to be desired.