Histopathologic and Flow Cytometric Analysis of Colorectal Polyps Resected at Endoscopy
作者:
H. Kimura,
M. Kanno,
H. Takamura,
H. Arakawa,
K. Maeda,
M. Uogishi,
H. Sodani,
T. Kawashima,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 3
页码: 187-192
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129277
出版商: S. Karger AG
关键词: Flow cytometry;DNA ploidy pattern;Colorectal polyps;Tubular adenoma
数据来源: Karger
摘要:
Forty-seven colorectal polyps of various histologic types were studied using retrospective flow cytometric (FCM) DNA analysis to determine the prevalence of aneuploid cell populations and whether they were associated with any particular histologic features. Overall, 6 of 47 polyps (12.8%) contained DNA aneuploid cells, comprising 4 adenomatous polyps, 1 of 12 with mild atypia (8.3 %), 2 of 19 with moderate atypia (10.5 %) and 1 of 4 with severe atypia (25.0%), and 2 of 4 polyps (50.0%) with histologic features of carcinoma in situ (CIS). The incidence of DNA aneuploid cells in CIS was significantly higher than that of all adenomatous polyps (p = 0.043). All of the 8 hyperplastic polyps were diploid. The detection of aneuploidy as a marker of increased risk for malignant transformation was possible even in colorectal adenomas measuring ≤ 10 mm. These results show that retrospective FCM analysis can detect DNA aneuploidy in adenomatous polyps and that DNA aneuploidy may occur before histologic evidence of invasive carcinom
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