Effect of Pimozide on Positive and Negative Symptoms in Schizophrenic Patients: Are Negative Symptoms State Dependent?
作者:
Daniel P. van Kammen,
Daniel W. Hommer,
Kenneth L Malas,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 18,
issue 3
页码: 113-117
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118403
出版商: S. Karger AG
关键词: Pimozide;Schizophrenia;Negative schizophrenic symptoms
数据来源: Karger
摘要:
In a double-blind, placebo-controlled trial of treatment with the neuroleptic pimozide, negative symptoms improved in schizophrenic patients who showed an antipsychotic response. Furthermore, there was a significant positive correlation between changes in positive and negative symptoms for the group as a whole, including both pimozide responders and nonresponders. In our patient sample, neuroleptic treatment did not exert a differential effect on the positive and negative symptoms of schizophrenia. It is conceivable that negative symptoms are state dependent and may become neuroleptic nonresponsive over time just as positive symptoms do in some chronic patients.
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