Pharmacologic Evaluation of Dopaminergic Receptor Blockade by Metoclopramide
作者:
Mohamed Hassan,
Avinoam Reches,
Cynthia Kuhn,
Donald Higgins,
Stanley Fahn,
期刊:
Clinical Neuropharmacology
(OVID Available online 1986)
卷期:
Volume 9,
issue 1
页码: 71-78
ISSN:0362-5664
年代: 1986
出版商: OVID
关键词: Metoclopramide;Locomotion;Rotation;Dopamine turnover;Prolactin
数据来源: OVID
摘要:
The occurrence of adverse extrapyramidal effects following metoclopramide (MCP) therapy has been well documented in humans. In rats, MCP produced catalepsy and inhibited apomorphine-induced stereotypy, locomotor activity, and rotational behavior. MCP also accelerated dopamine turnover, potently stimulated prolactin release, and, at high concentrations, inhibited [3H]spiperone binding to striatal membranes. These behavioral and biochemical effects induced by MCP were similar to those observed with haloperidol. We conclude that MCP possesses most of the pharmacological properties of neuroleptic agents.
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