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Prednisolone Promotes the Secretion of Progesterone and Oestradiol by Luteinised Granulosa Cells Independent of Human Chorionic Gonadotropin

 

作者: W. Würfel,   T. Steck,   I. v.Hertwig,   P. Albert,  

 

期刊: Gynecologic and Obstetric Investigation  （Karger Available online 1990）
卷期: Volume 29, issue 3  

页码: 188-191

 

ISSN:0378-7346

 

年代: 1990

 

DOI:10.1159/000293374

 

出版商: S. Karger AG

 

关键词: In vitro fertilisation;Human chorionic gonadotropin receptor;Secretion of progesterone;Secretion of oestradiol;Granulosa cells;luteinised;Glucocorticoids;Aromatase activity;Artificial stimulation of cycle

 

数据来源: Karger

 

摘要:

An in vitro model based on luteinised granulosa cells gained during an in vitro fertilisation programme examines the question of whether prednisolone, and thus glucocorticoids in general, are capable of exerting an influence on the secretion of oestradiol and progesterone. It can be demonstrated that prednisolone leads to dosage-dependent increases in the concentration of both steroids, even independently of concurrent stimulation by human chorionic gonadotropin. A similar mechanism for aromatase activity of human adipose cells is suggested.

 

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