Extracellular matrix biologya new frontier in linking the pathology and therapy of hypertension?
作者:
Muzahir Tayebjee,
Robert MacFadyen,
Gregory Lip,
期刊:
Journal of Hypertension
(OVID Available online 2003)
卷期:
Volume 21,
issue 12
页码: 2211-2218
ISSN:0263-6352
年代: 2003
出版商: OVID
关键词: extracellular matrix;matrix metalloproteinases;collagen
数据来源: OVID
摘要:
The extracellular matrix (ECM) is a vital component of connective tissue, and collagen is a major constituent. There is growing evidence that changes in the composition of the cardiac and vascular matrix occurs during hypertension. Clinically, these effects are manifested as left ventricular hypertrophy and a reduction in arterial compliance and luminal diameter, which results in end organ ischaemia. The matrix metalloproteinases and their inhibitors have a central role in the regulation of the composition of the ECM. In this review, we discuss the mediators that affect the structure of the ECM in hypertension using results from animal and human studies.
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