Induction of Ovulation – Past, Present and Future
作者:
Raphael Jewelewicz,
Paul R. Gindoff,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1988)
卷期:
Volume 26,
issue 2
页码: 89-103
ISSN:0378-7346
年代: 1988
DOI:10.1159/000293679
出版商: S. Karger AG
关键词: Human menopausal gonadotropins;Human chorionic gonadotropins;Clomiphene citrate;Gonadotropin-releasing hormone;Opioid peptides
数据来源: Karger
摘要:
Attempts to induce ovulation have been made since the early 1920s, but the major breakthrough came in the early 1960s with the introduction of clomiphene citrate and the gonadotropins. Additional progress was made in the early 1970s with the introduction of bromocriptine and in the early 1980s with the introduction of pulsatile GnRH. At the present, ‘pure’ FSH and GnRH agonists are being evaluated as adjuncts to HMG for induction of ovulation. As more insight is gained in the neuroendocrine control of the ovulating cycle, we may soon be able to induce ovulation by direct manipulation of the central nervous system.
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