Influence of methisoprinol (lsoprinosine) on hiv‐infected human lymphocytes: In vitro immunological, virological, and ultrastructural studies
作者:
Claudio De Simone,
Federico DeMarco,
Giuseppe Arancia,
Sonia Tzantzoglou,
Silvia Paradisi,
Franco Sorice,
期刊:
Journal of Clinical Laboratory Analysis
(WILEY Available online 1989)
卷期:
Volume 3,
issue 1
页码: 26-33
ISSN:0887-8013
年代: 1989
DOI:10.1002/jcla.1860030107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: methisoprinol;isoprinosine;HIV;AIDS
数据来源: WILEY
摘要:
AbstractMethisoprinol (isoprinosine) is a synthetic compound with reported antiviral and immunomodulating properties. Results of the present study showed that methisoprinol at concentrations ≥ 200 μg/ml reduces the p24 and gp120 viral antigen expression on the surface of human immunodeficiency virus (HIV)‐infected lymphocytes and the reverse transcriptase levels. In addition, cell viability, the number of the CD4 + cells, and the CD4 + /CD8+ cell ratio are higher in methisoprinol‐pretreated cell suspensions than in untreated HIV‐infected cell cultures. A quantitative freeze‐fracture study on the density of the intramembranous particles (IMP) present on both fracture faces of the plasma membrane of lymphocytes has shown that pretreatment with methisoprinol induces a different molecular organization resulting in a nearly three times increase of I
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