Capsaicin enhances allergic contact dermatitis in the guinea pig
作者:
Joanna Wallengren,
Rolf Ekman,
Halvor Möller,
期刊:
Contact Dermatitis
(WILEY Available online 1991)
卷期:
Volume 24,
issue 1
页码: 30-34
ISSN:0105-1873
年代: 1991
DOI:10.1111/j.1600-0536.1991.tb01626.x
出版商: Blackwell Publishing Ltd
关键词: allergic contact dermatitis;substance P;capsaicin;guinea pig sensitization;dintrochlorobenzene;enhancing effect
数据来源: WILEY
摘要:
Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously tin the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well us by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization, In comparison with controls, the contact dermatitis was Enhanced in both groups of animals treated with capsaicin.
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