Prospective Controlled Study of Androgen Effects on Red Cell Oxygen Transport and Work Capacity in Chronic Hemodialysis Patients
作者:
Ernesto D. Hendler,
Lawrence R. Solomon,
期刊:
Acta Haematologica
(Karger Available online 1990)
卷期:
Volume 83,
issue 1
页码: 1-8
ISSN:0001-5792
年代: 1990
DOI:10.1159/000205154
出版商: S. Karger AG
关键词: Androgens;Anemia;Exercise tolerance tests;Hemodialysis;Oxygen transport
数据来源: Karger
摘要:
Effects of androgens on red blood cell (RBC) oxygen transport, RBC metabolism and work capacity in chronic hemodialysis patients were evaluated in a prospective controlled study. Compared to control subjects, patients given nandrolone decanoate had a sustained fall in RBC ATP and a transient rise in RBC DPG but P50 values were unchanged. Despite increases in RBC mass of 16–44% on androgen therapy, excercise on the treadmill improved in only 1 patient and actually declined in 3 others. Thus, these preliminary observations suggest that androgens may not improve hemoglobin-oxygen transport and that androgen-induced increases in red cell mass may only balance increased tissue oxygen requirements produced by these anabolic hormone
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