Effects of Neutral and Dibasic Ammo Acids on thein vitroRelease of Insulin
作者:
Å. Lernmark,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1972)
卷期:
Volume 3,
issue 1
页码: 22-30
ISSN:1663-2818
年代: 1972
DOI:10.1159/000178254
出版商: S. Karger AG
关键词: Dibasic amino acids;Insulin release;Isolated islets;Mice;Neutral amino acids;Receptor sites;Transport sites
数据来源: Karger
摘要:
The insulin-releasing ability of some neutral and dibasic amino acids was studied in an in vitro system using micro dissected pancreatic islets with a high proportion of insulin-producing β-cells. The neutral amino acids L-alanine and α-aminoisobutyric acid had no substantial effects on basal and glucose stimulated insulin release. In contrast, 5–20 mM of the dibasic amino acid L-arginine gradually enhanced the insulin release induced by 10 mM glucose. A critical glucose concentration must be reached before L-arginine can act as an insulin secretagogue. N-methyl-L-arginine lacked the stimulatory ability. Co-transport of neutral amino acids and sodium does not elicit insulin release in adult mouse β-cells. There may, however, be a close relationship between the transport site for L-arginine and a receptor triggering insulin rel
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