首页   按字顺浏览 期刊浏览 卷期浏览 Formation of Active Oxygen Species by Dithranol, III Dithranol, Active Oxygen Species a...
Formation of Active Oxygen Species by Dithranol, III Dithranol, Active Oxygen Species and Lipid Peroxidation in vivo

 

作者: Klaus Müller,   Wolfgang Wiegrebe,   Maged Younes,  

 

期刊: Archiv der Pharmazie  (WILEY Available online 1987)
卷期: Volume 320, issue 1  

页码: 59-66

 

ISSN:0365-6233

 

年代: 1987

 

DOI:10.1002/ardp.19873200110

 

出版商: WILEY‐VCH Verlag

 

数据来源: WILEY

 

摘要:

AbstractAt pH 7.8 the dithranol anion1ais oxidized in the dark to yield the bianthrone3besides dithranol brown, whilst O2is reduced to O2·−and H2O2. O2·−was detected by the reduction of nitroblue‐tetrazolium (NBT,4). The formation of the formazan5was inhibited by superoxide dismutase (SOD). Exclusion of O2and addition of SOD reveal a direct electron transfer from1ato4and to cytochrome c which was not affected in the presence of SOD. —In vivoexperiments indicate a low rate of lipid peroxidation which was determined on the basis of ethane e

 

点击下载:  PDF (372KB)



返 回