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Efficacy of Oral Administration of Ofloxacin in Lower Respiratory Tract Infections in Aged Patients with Chronic Lung Disease

 

作者: Makoto Yamaoka,   Yoshinosuke Fukuchi,   Masatoshi Yokouchi,   Nobutsugu Teramoto,   Takahide Nagase,   Kiyoshi Ishida,   Eiichi Ohtomo,   Hajime Orimo,  

 

期刊: Chemotherapy  （Karger Available online 1991）
卷期: Volume 37, issue 1  

页码: 14-18

 

ISSN:0009-3157

 

年代: 1991

 

DOI:10.1159/000238901

 

出版商: S. Karger AG

 

关键词: Ofloxacin;Elderly;Respiratory infection;Arterial oxygen pressure;Helper/suppressor T cell ratio;Natural killer cells;Interleukin-2;Superoxide production

 

数据来源: Karger

 

摘要:

The efficacy of ofloxacin for the treatment of lower respiratory tract infection was evaluated in aged patients with chronic lung disease. Results are the following: improvement of leukocytosis and arterial oxygen tension was observed; peripheral blood cell analysis showed a decrease in natural killer cell counts and in helper/suppressor T cell ratio; superoxide production by peripheral blood white cells was decreased after treatment; interleukin-2 production was rather increased. We concluded that improvement in the immunological parameters indicated the efficacy of ofloxacin for lower respiratory tract infection in aged patients with chronic lung disease.

 

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