Role of Homocytotropic Antibodies in Pathogenesis of Gastric Ulcer
作者:
F. André,
C. André,
J.L. Vialard,
期刊:
Digestion
(Karger Available online 1979)
卷期:
Volume 19,
issue 3
页码: 175-179
ISSN:0012-2823
年代: 1979
DOI:10.1159/000198341
出版商: S. Karger AG
关键词: Anaphylaxis;Disodium cromoglycate;Gastric ulcer;Immunoglobulins;Mast cells
数据来源: Karger
摘要:
Praomys (Mastomys) natalensis were sensitised by peritoneal injection of ovalbumin mixed with aluminium hydroxide. The animals developed homocytotropic IgE and IgG 1 antibodies. When presensitised animals were challenged with ovalbumin in the gastric wall, a gastric ulcer appeared. This ulceration, induced by an immunological release of histamine, could be inhibited by the administration of disodium cromoglycate. The present model is useful for producing a gastric ulcer in a determined site. It supports the theory of a possible allergic component in the pathogenesis of the human disease.
点击下载:
PDF
(626KB)
返 回