Thirty patients have been treated with Rifampicin, ethambutol and/or other drugs. All had long-standing advanced tuberculosis with organisms resistant to the standard and often to older ‘reserve’ drugs. Four discharged themselves during the first month of treatment. Of the remaining 26, 24 have persistently negative cultures for M. tuberculosis, in 14 patients for 1 to 20 months after the end of two years of treatment. Tolerance was excellent and toxicity virtually abs