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Specific Effect of Age on Lectin-Induced Mitogenesis of Lymphocytes from Diseased Patients

 

作者: Dany Brohée,   Viviane de Maertelaer,   Pietrina Piro,   Bernard Kennes,   Pierre Nève,  

 

期刊: Gerontology  （Karger Available online 1986）
卷期: Volume 32, issue 2  

页码: 74-80

 

ISSN:0304-324X

 

年代: 1986

 

DOI:10.1159/000212769

 

出版商: S. Karger AG

 

关键词: Human lymphocyte;Multivariate analysis;Monoclonal antibodies;Capping;Phytohemagglutinin A

 

数据来源: Karger

 

摘要:

Using several models of multivariate analysis, it is found that age per se is a specific determinant on the in vitro lymphocyte response to phytohemagglutinin A in a random sample of 30 diseased patients. Depending upon the used model, sex and lymphocyte subsets appear as other significant variables. The multiple regression coefficients reach 0.85. A 2% fall per decade is expected for phytohemagglutinin A responsiveness expressed in In cpm.

 

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