Effects of Phenobarbitone on the Distribution, Metabolism and Biliary Excretion of Erythromycin in Rats
作者:
L. Manzo,
C. Gregotti,
P. Richelmi,
A. Di Nucci,
F. Bertè,
期刊:
Chemotherapy
(Karger Available online 1980)
卷期:
Volume 26,
issue 3
页码: 164-170
ISSN:0009-3157
年代: 1980
DOI:10.1159/000237900
出版商: S. Karger AG
关键词: Erythromycin;Phenobarbitone;Biliary excretion;Drug metabolism;Distribution
数据来源: Karger
摘要:
The administration of phenobarbitone to the rat (8 mg/100 g BW) once daily for 3 days significantly decreased the serum and tissue levels of erythromycin administered intraperitoneally (5 mg/l00 g BW). Furthermore, phenobarbitone stimulated the hepatic microsomal N-demethylation of erythromycin and increased the biliary concentration and the biliary excretion rate of the unmetabolized antibiotic. These effects were accompanied by augmented liver mass and bile flow. The possibility is discussed that erythromycin concentrates in the bile through a specialized hepatic drug transport system, activated by phenobarbitone.
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