Fulminant pneumococcal meningitis was the presenting manifestation of a chromophobe adenoma of the pituitary in an asymptomatic healthy young man. Routine skull radiography revealing an enlarged destroyed sella turcica identified the primary pathology. Erosion into the sphenoid sinus, presumably by opening up a portal of entry for pyogenic bacteria into the cranial cavity, resulted in one of the rarest modes of presentation of pituitary neoplasm. The importance of corticosteroids in therapy is discussed.