Effects of Chinese herbs on macrophage functions in N-butyl-N-butanolnitrosoamine treated mice
作者:
JinR.,
KurashigeS.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1996)
卷期:
Volume 18,
issue 1
页码: 105-114
ISSN:0892-3973
年代: 1996
DOI:10.3109/08923979609007113
出版商: Taylor&Francis
关键词: Chinese herbs;Carcinogen (N-butyl-N-butanolnitrosoamine);Macrophage;Cytokine production
数据来源: Taylor
摘要:
AbstractWe investigated the effect of Chinese herbs Lithospermi radix, Astragali radix and Cnidii rhizoma on the functions of macrophages obtained from mice treated with the carcinogen N-butyl-N-butanolnitrosoamine (BBN). The chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with BBN compared with controrls. Production of IL-1 and TNF was also markedly reduced. Treatment with Lithospermi radix, Astragali radix, and Cnidii rhizoma significantly inhibited BBN-induced suppression chemotactic activity and production of IL-1 and TNF-αby macrophages. Moreover, we found that Astragali radix treated macrophage chemotaxis, it or Cnidii rhizoma induced productions of TNF-αwere in excessed of control.
点击下载:
PDF (342KB)
返 回