Evaluation of Cellular Immune Responses and Soluble Mediators in Patients with Chronic Hepatitis c Virus (CHCV) Infection
作者:
JirilloEmilio,
GrecoBeatrice,
CaradonnaLuigi,
SatalinoRosa,
PuglieseVittorio,
CozzolongoRaffaele,
CupponeRenato,
ManghisiOnofrio G.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1995)
卷期:
Volume 17,
issue 2
页码: 347-364
ISSN:0892-3973
年代: 1995
DOI:10.3109/08923979509019756
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractIn 54 patients with cHCV infection, peripheral immune responsiveness and soluble mediator release were evaluated. Results demonstrate that in these patients phagocytosis and killing capacities exerted by polymorphonuclear cells and monocytes were profoundly depressed. At the same time, absolute numbers of CD3+, CD8+ and CD16+ cells were reduced, while the CD4+ -CD8+ dependent antibacterial activity was also impaired.With special reference to soluble mediators, elevated amounts of both soluble interleukin-2 receptor and soluble intercellular adhesion molecule-1 were detected in sera of patients. By contrast, serum levels of tumor necrosis factor-αwere within normal ranges, whereas interferon-γserum concentrations were decreased. of note, in 18,5% of cHCV patients circulating levels of bacterial lipopolysaccharides (LPS) were detected by means of Limulus assay. In the Limulus + subset of patients, absolute numbers of CD14+ cells were reduced in a significant manner, this implying a putative monocyte-LPS interaction.In conclusion, the overall results indicate a condition of peripheral immune depression in cHCV patients with an exaggerated shedding of various mediators endowed with noxious effects for the host.
点击下载:
PDF (684KB)
返 回