Maternal cytomegalovirus infection is a relatively common, yet very often silent complication of pregnancy. The association between early gestational wastage and cytomegalovirus endometritis has been documented in recent tissue culture studies without the morphologic demonstration of the virus. This case study presents the clinical and pathologic findings of a young, secundigravida female with cytomegalovirus endometritis and spontaneous abortion. The intranuclear inclusions were restricted to the endometrial glands. Involvement of the endocervix by cytomegalovirus has been the only site in the female reproductive tract, excluding fetal tissues, affected by this virus which has been demonstrated histologically. The data are still incomplete regarding the etiologic role, if any, of cytomegalovirus and the occurrence of spontaneous abortion.