Antiallergic drugs and the immune response
作者:
G. W. Canonica,
G. Ciprandi,
期刊:
Allergy
(WILEY Available online 1989)
卷期:
Volume 44,
issue 1
页码: 1-5
ISSN:0105-4538
年代: 1989
DOI:10.1111/j.1398-9995.1989.tb00438.x
出版商: Blackwell Publishing Ltd
关键词: allergic diseases;antiallergic drugs;immune response
数据来源: WILEY
摘要:
Since the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy and possible concomitant infections, we have investigated the possible effects of such drugs as cromolyn, theophylline, ketotifen, oxatomide, astemizole, fenoterol, pirenzepine, and rosaprostol on thein vitroimmune response, in order to obtain experimental data and, as a consequence, clinical conclusions. In a series of investigations by our group and other authors the following immunological parameters have been considered: T cell activation induced by different pathways (i.e. autologous stimulation, PHA, anti‐CD3, ‐CD2 and ‐CD28 monoclonal antibodies), and lymphokine production (i.e. IL‐1, IL‐2 and gamma‐IFN). For a more detailed experimental model the experiments have been performed both in bulk culture and by using T cell clones derived from the peripheral blood. The results show cromolyn to have an enhancing effect, theophylline and ketotifen a suppressing effect, whereas the remainder show no effect on the immune response. These data are considered and discussed from the aspect of their possible clinical relevance and also in light of the in vivo data previous
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