The purpose of this research was to investigate differential manifestation of depressive symptomatology among adolescents from diverse ethnocultural groups. Data from a national survey of persons 12 to 17 years of age (N=2200) were analyzed, comparing responses of Anglo, African, Mexican, and other Hispanic Americans with a 12-item version of the Center for Epidemiologic Studies Depression Scale. The results indicated minimal differences in terms of item response and internal consistency-reliability among the four adolescent groups. However, there were differences in patterns of item endorsement, as indicated by principal component factor analysis. Anglo- and African Americans exhibited similar factor structure, represented by negative affect, positive affect, and psychosomatic symptoms. The two Hispanic groups also exhibited a three-dimensional pattern, but there was a tendency among Hispanic adolescents for somatic symptoms and negative affect symptoms to cluster together. This pattern may indicate a more prominent role of somatic complaints in the presentation of depression among Mexican Americans and other Hispanics.