The application of repeated skin homografts from the same rabbit of guinea pig donor, under the experimental conditions described, even when performed for as long as 42 consecutive weeks, does not result in desensitization of the recipient to such grafts. Rather, such grafts continue to be rejected as white grafts. These results suggest that: (a) white graft responses may be an expression of a higher level of sensitivity than accelerated rejection, and (b) although white grafts do not become vascularized, they maintain the recipient's heightened state of homograft sensitivity to subsequent grafts from the same donor.