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A3H-Flunitrazepam Binding Inhibitor is Present in Psychiatric Patients’ Sera

 

作者: Donatella Marazziti,   Pietro Pietrini,   Claudia Martini,   Gino Giannaccini,   Giulio Perugi,   Gian Franco Placidi,   Gino Battista Cassano,   Antonio Lucacchini,  

 

期刊: Neuropsychobiology  （Karger Available online 1987）
卷期: Volume 18, issue 2  

页码: 74-76

 

ISSN:0302-282X

 

年代: 1987

 

DOI:10.1159/000118396

 

出版商: S. Karger AG

 

关键词: Benzodiazepines;Specific receptor;Endogenous ligand;Human serum;Anxiety;Depression

 

数据来源: Karger

 

摘要:

We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-fiunitrazepam binding specifically in the samples taken from the patients’ groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiet

 

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