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Variant Multiple Endocrine Neoplasia I (MEN IBurin): Further Studies and Non-Linkage to HLA

 

作者: John C. Bear,   Rosario Briones-Urbina,   James F. Fahey,   Nadir R. Farid,  

 

期刊: Human Heredity  (Karger Available online 1985)
卷期: Volume 35, issue 1  

页码: 15-20

 

ISSN:0001-5652

 

年代: 1985

 

DOI:10.1159/000153508

 

出版商: S. Karger AG

 

关键词: MEN I;HLA;Prolactinoma;Genetic linkage

 

数据来源: Karger

 

摘要:

We have extended our study of an incomplete variant of multiple endocrine neoplasia Type I (MEN IBurin). In this syndrome, primary hyperparathyroidism and prolactin-secreting adenoma are common, with hormone-secreting pancreatic tumors being rarely seen. The recent localization of the prolactin structural gene to chromosome 6 made further investigation of linkage to HLA of particular interest. Results in 2 multigeneration families exclude close linkage to HLA. We cannot at this time draw any inference regarding linkage of MEN IBurin to the prolactin structural gene.

 

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