Variant Multiple Endocrine Neoplasia I (MEN IBurin): Further Studies and Non-Linkage to HLA
作者:
John C. Bear,
Rosario Briones-Urbina,
James F. Fahey,
Nadir R. Farid,
期刊:
Human Heredity
(Karger Available online 1985)
卷期:
Volume 35,
issue 1
页码: 15-20
ISSN:0001-5652
年代: 1985
DOI:10.1159/000153508
出版商: S. Karger AG
关键词: MEN I;HLA;Prolactinoma;Genetic linkage
数据来源: Karger
摘要:
We have extended our study of an incomplete variant of multiple endocrine neoplasia Type I (MEN IBurin). In this syndrome, primary hyperparathyroidism and prolactin-secreting adenoma are common, with hormone-secreting pancreatic tumors being rarely seen. The recent localization of the prolactin structural gene to chromosome 6 made further investigation of linkage to HLA of particular interest. Results in 2 multigeneration families exclude close linkage to HLA. We cannot at this time draw any inference regarding linkage of MEN IBurin to the prolactin structural gene.
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