Feedback Regulation of Pancreatic Enzyme Secretion by Intestinal Trypsin in Man
作者:
I. Ihse,
P. Lilja,
I. Lundquist,
期刊:
Digestion
(Karger Available online 1977)
卷期:
Volume 15,
issue 4
页码: 303-308
ISSN:0012-2823
年代: 1977
DOI:10.1159/000198016
出版商: S. Karger AG
关键词: Amylase;Bile ducts;Cholangiography;percutaneous;Lipase;Pancreatic neoplasm;Pancreatic secretion;Trypsin;Papilla of Vater
数据来源: Karger
摘要:
In a patient a papilla Vateri tumor completely prevented the bile-pancreatic flow into the intestine although the pancreatic juice was secreted into the bile duct via a common channel. Consequently, the bile-pancreatic juice was possible to sample via a percutaneous transhepatic cholangiography (PTC) catheter. This made it possible to study the effect of duodenal infusion of different substances on the bile-pancreatic secretion. In repeated experiments a suppression of the secretion was observed by intraduodenal trypsin as well as the patient’s own bile-pancreatic juice. In the presence of bile-pancreatic juice intraduodenal trypsin inhibitor infusion caused a marked stimulation of the secretion. The results are in accordance with the hypothesis that trypsin in the upper part of the intestine exerts a negative feedback regulation of the pancreatic secretion in ma
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