Nuclear/growth factors
作者:
A. Prochiantz,
L. Théodore,
期刊:
BioEssays
(WILEY Available online 1995)
卷期:
Volume 17,
issue 1
页码: 39-44
ISSN:0265-9247
年代: 1995
DOI:10.1002/bies.950170109
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe now classical model for cell‐cell communication espouses that information travels between cells in the form of molecules that bind specific cell‐surface receptors and trigger signal‐transducing mechanisms that eventually lead to transcriptional modifications. Here we gather the available information suggesting that some growth factors may also act by interfering directly with gene transcription, following their internalization and nuclear translocation. Among these factors arebona fidegrowth factors such as Fibroblast Growth Factor‐1 and ‐2 and Schwannoma Derived Growth Factor, for which internalization and nuclear translocation have been demonstrated. Conversely, we propose that some isoforms of nuclear factors of the homeoprotein family could pass from cell to cell. The implications of the model are presented in the context of the specificity of cellular int
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