Immunocytochemical Localization of Keratin in Normal, Dysplastic and Neoplastic Cervical Epithelium
作者:
Vladimir Bychkov,
Gregorio Chejfec,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1984)
卷期:
Volume 18,
issue 1
页码: 1-5
ISSN:0378-7346
年代: 1984
DOI:10.1159/000299040
出版商: S. Karger AG
关键词: Keratin;Immunocytochemistry;Cervix;Neoplasia;Dysplasia;Condyloma
数据来源: Karger
摘要:
The PAP immunocytochemical technique utilizing specific keratin antibody was applied to paraffin sections from 36 cervical biopsies. Normal squamous eptihelium and condylomas had similar patterns of keratin production with intense staining of intermediate and upper layers, while basal cells remained negative. Dysplasia, carcinoma in situ and infiltrating squamous carcinoma showed uneven distribution of keratin with the least amount seen in the areas with high mitotic rate and anaplasia. All large cell squamous carcinomas demonstrated presence of significant amouts of keratin. Squamous carcinomas of the small cell type were essentially keratin-free.
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