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Kinetic Investigation on the Degradation of Lorazepam in Acidic Aqueous Solutions by High Performance Liquid Chromatography

 

作者: I.E. Panderi,   H.A. Archontaki,   E.E. Gikas,   M. Parissi-Poulou,  

 

期刊: Journal of Liquid Chromatography & Related Technologies  （Taylor Available online 1998）
卷期: Volume 21, issue 12  

页码: 1783-1795

 

ISSN:1082-6076

 

年代: 1998

 

DOI:10.1080/10826079808005891

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

A high performance liquid chromatographic method was developed for the kinetic investigation on the acidic hydrolysis of lorazepam in 0.01, 0.1, and 1.0 M hydrochloric acid solutions. In this study, the simultaneous determination of lorazepam and its main degradation product was performed on a reversed phase BDS C-8 column. The mobile phase consisted of a mixture of methanol: acetonitrile: buffer solution containing 0.005 M KH

 

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