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Mapping of thebcl-2oncogene on mouse chromosome 1

 

作者: B.A. Mock,   D. Givol,   L.A. Dhoostelaere,   K. Huppi,   M.F. Seldin,   N. Gurfinkel,   T. Unger,   M. Potter,   J.F. Mushinski,  

 

期刊: Cytogenetic and Genome Research  （Karger Available online 1988）
卷期: Volume 47, issue 1-2  

页码: 11-15

 

ISSN:1424-8581

 

年代: 1988

 

DOI:10.1159/000132495

 

出版商: S. Karger AG

 

数据来源: Karger

 

摘要:

Two bcl-2 alleles have been identified in inbred strains of mice by restriction fragment length polymorphism (RFLP). Analysis of a bcl-2 RFLP in a series of bilineal congenic strains (C.D2), developed as a tool for chromosomal mapping studies, revealed linkage of bcl-2 to the Idh-1/Pep-3 region of murine chromosome 1. The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1 in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2.

 

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