Effects of Endocrine Glands and Hormone Replacement on the Mast Cell Count of the Harderian Gland of Mice
作者:
Kazuhiko Shirama,
Masanori Kohda,
Masami Hokano,
期刊:
Cells Tissues Organs
(Karger Available online 1988)
卷期:
Volume 131,
issue 4
页码: 327-331
ISSN:1422-6405
年代: 1988
DOI:10.1159/000146535
出版商: S. Karger AG
关键词: Harderian gland;Mast cell;Steroid hormones;Mouse
数据来源: Karger
摘要:
There are marked sex differences in the Harderian gland of the C3H/He mouse strain, the females having a larger number of mast cells than the males as one of the major differences. Mast cell counts of the Harderian gland were made on male mice subjected to combinations of adrenalectomy, gonadectomy and administration of sex steroid hormones. Castration alone caused a significant increase in the count resulting in about three times the number found in intact males. Castration plus adrenalectomy increased the count over 6-fold, to levels close to those found in female mice. Administration of testosterone or estrone to the mice which had been castrated and adrenalectomized prevented the increase, while progesterone treatment had no effect on the count. Although the number of mast cells in the male Harderian gland was necessarily small compared to either the female gland or that of castrated and adrenalectomized males, no obvious dimorphism could be found microscopically.
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