Renal Urate Excretion in Normal Man
作者:
Thomas H. Steele,
Richard E. Rieselbach,
期刊:
Nephron
(Karger Available online 1975)
卷期:
Volume 14,
issue 1
页码: 21-32
ISSN:1660-8151
年代: 1975
DOI:10.1159/000180433
出版商: S. Karger AG
关键词: Uric acid;Urate;Organic acids;Tubular secretion
数据来源: Karger
摘要:
The development of our knowledge of the intrarenal processes involved in the control of urate excretion in normal man is summarized. Although there are many gaps in our current knowledge, and different interpretations may be given to the available data, current evidence seems to favor the existence of extensive tubular reabsorption of urate following its glomerular filtration. Subsequently, tubular secretion of urate and the reabsorption of an unknown amount of the secreted urate probably take place. For reasons discussed, it seems most likely that the regulation and control of urate excretion are accomplished through modulations in tubular secretion, post-secretory reabsorption, or both.
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