Pulmonary Hypertension Induced in Rats by Monocrotaline and Chronic Hypoxia is Reduced byp-Chlorophenylalanine
作者:
J.M. Kay,
P.M. Keane,
K.L. Suyama,
期刊:
Respiration
(Karger Available online 1985)
卷期:
Volume 47,
issue 1
页码: 48-56
ISSN:0025-7931
年代: 1985
DOI:10.1159/000194748
出版商: S. Karger AG
关键词: Pulmonary hypertension;Right ventricular hypertrophy;Pulmonary vascular disease;Monocrotaline;Chronic hypoxia;5-Hydroxytryptamine;p-Chlorophenylalanine;Rats
数据来源: Karger
摘要:
We have studied the role of 5-hydroxytryptamine (5-HT) in monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats using p-chlorophenylalanine (PCPA) which inhibits 5-HT synthesis. We measured right ventricular mean systolic pressure (Prvs), right ventricular hypertrophy, medial thickness of muscular pulmonary arteries, and muscularization of pulmonary arterioles 17 days after a single dose of monocrotaline (60 mg/kg) and after 26 days of chronic hypobaric hypoxia (380 mm Hg). In monocrotaline pulmonary hypertension, pretreatment with PCPA (500 mg/kg) was associated with significant reductions (p < 0.05) in Prvs (29%), right ventricular hypertrophy (33%), and medial thickness of muscular pulmonary arteries (14%). In chronic hypoxic pulmonary hypertension, pretreatment with PCPA was associated with significant reductions in Prvs (20%), right ventricular hypertrophy (28%), medial thickness of muscular pulmonary arteries (14%), and muscularization of pulmonary arterioles (47%). 5-HT may play a role in the development of monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats.
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