Surface la-Like Expression and MLR-Stimulating Capacity of Human Leukemic Myeloblasts: Implications for Immunotherapy and Prognosis
作者:
T.D. Miale,
L.Å.L. Stenke,
J.B. Lindblom,
A.-M. Sjögren,
P.G. Reizenstein,
A.-M. Udén,
D.L. Lawson,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 68,
issue 1
页码: 3-13
ISSN:0001-5792
年代: 1982
DOI:10.1159/000206941
出版商: S. Karger AG
关键词: Surface la;Human leukemia
数据来源: Karger
摘要:
Surface la-positive cells were found to vary from 0 to 100% in initial blood specimens from 37 adults with acute myelogenous leukemia (AML). When myeloblasts from 19 patients were tested against panels of lymphocytes from 5 to 19 normal donors, mean stimulation indices ranged from 1 to 60. Some leukemic myeloblasts strongly stimulated most allogenic responder lymphocytes whereas others produced almost no stimulation. The addition of antibody against human la to 28 mixed leukocyte reaction (MLR) combinations resulted in significant inhibition (p < 0.001) of 3 50% la-positive myeloblasts had a significantly longer survival than patients with fewer la-positive myeloblasts (p < 0.04).
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