Ultrastructural Changes in the Trabecular Meshwork of Juvenile Glaucoma
作者:
Naohiko Furuyoshi,
Miki Furuyoshi,
Ryusuke Futa,
Johannes Gottanka,
Elke Lütjen-Drecoll,
期刊:
Ophthalmologica
(Karger Available online 1997)
卷期:
Volume 211,
issue 3
页码: 140-146
ISSN:0030-3755
年代: 1997
DOI:10.1159/000310781
出版商: S. Karger AG
关键词: Juvenile glaucoma;Steroid-induced glaucoma;Extracellular material;Trabecular meshwork;Image analysis
数据来源: Karger
摘要:
Trabeculectomy specimens from 11 patients with juvenile glaucoma were studied by electron microscopy and quantitatively evaluated. In all cases, large amounts of extracellular material arranged in a fingerprint-like pattern, resembling basement-membrane-like material (FBM) was found, similar to that described in steroid-induced glaucoma. This material was found mainly within the inner cribriform and outer corneoscleral regions of the trabecular meshwork, and caused the cribriform layer to be greatly thickened. FBM was also intimately associated with trabecular cells, which frequently appeared activated. In 3 cases, there was also an increase in fine fíbrillar material which resembled that found in eyes with steroid-induced glaucoma. The amount of sheath-derived plaque material, which is increased in primary open angle glaucoma, was greatly increased in the subendothelial layer adjacent to Schlemm’s canal.
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