AbstractIntraperitoneal administration of quercetin (6.25–50 mg/kg) significantly (p<0.5‐0.01) reduced intestinal transit in mice and this effect was antagonized by yohimbine and phentolamine but not by atropine or naloxone. Quercetin (12.5–50 mg/kg) reduced also (p<0.05‐0.01) intraluminal accumulation of fluid and diarrhoea induced by castor oil and these effects were antagonized by yohimbine. Finally quercetin (12.5–50 mg/kg) reduced the area of gastric ulcer but not the number. It is suggested that α2‐adrenergic receptors mediate the effect of quercetin on intestinal motility a