Immunohistochemical demonstration of placental alkaline phosphatase in various states of testicular development and in germ cell tumours
作者:
J. HUSTIN,
J. COLLETTE,
P. FRANCHIMONT,
期刊:
International Journal of Andrology
(WILEY Available online 1987)
卷期:
Volume 10,
issue 1
页码: 29-35
ISSN:0105-6263
年代: 1987
DOI:10.1111/j.1365-2605.1987.tb00162.x
出版商: Blackwell Publishing Ltd
关键词: Placental alkaline phosphatase;immunocytochemistry;embryonic testis;testicular carcinoma‐in‐situ;seminoma
数据来源: WILEY
摘要:
Immunohistochemical localization of placental alkaline phosphatase (PlAP) has been performed on eighty‐two samples of normal (embryonic, fetal, infantile or adult), cryptorchid or tumorous testicular tissue. The isoenzyme could be demonstrated at the cell membrane of primitive, embryonic germ cells but not in other normal tissues. In‐situ carcinomas and seminomas were positively stained in 93% and 94% of cases respectively. The percentage of positivity decreased with tumour differentiation. It is suggested that PlAP is a marker of primitive germ cells and that it reappears in germ cell neoplasms by gene derepress
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