Factor VII Padua Defect: The Heterozygote Population
作者:
A. Girolami,
Dal Bo Zanon,
F. Zanella,
M. Procidano,
G. Ruffato,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 68,
issue 1
页码: 34-38
ISSN:0001-5792
年代: 1982
DOI:10.1159/000206945
出版商: S. Karger AG
关键词: Prothrombin time;Factor VII abnormality;Factor VII defect
数据来源: Karger
摘要:
14 heterozygote patients, belonging to three families with factor VII Padua defect were investigated. All patients were asymptomatic but presented a mild prolongation of prothrombin time. Factor VII activity varied between 45 and 61% of normal and no overlap was found with the homozygous or the normal populations. On the contrary, factor VII cross-reacting material was normal. A good negative correlation was found between factor VII level and prothrombin times. All patients came from the same valley of northeastern Italy. This valley, the Piave river valley, is not far from the valley.where the factor X Friuli defect was found. The significance of this peculiar geographical distribution of the two abnormalities is unknown.
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