Using a sample of 209 volunteer students between the ages of 18 and 25 from an urban university, the relationships betwen self-disclosure, interpersonal dependency, life changes, and lonelines were stdied. Respondents completed the Jourard 40-Item Self-Disclosure Questrionnaire, the Interpersonal Dependency Inventory, the Recent Life Change Questionnaire, and the revised UCLA Loneliness Scale. Pearson productmoment correlation coefficients and miutiple regression analysis were used to test the hypotheses. Hypotheses were supported predicting an inverse relationship between self-dsclosure and loneliness (p < .005) and a positive relationship between interpersonal dependency and loneliness (p < .005). However, a positive relationship between life changes and loneliness was not supported. Data also supported the hypothesis that self-disclosure, interpersonal dependency, and life changes would account for greater variance in loneliness than any single variable alone (F(3,204), p < .01). From a stepwise multiple regression analysis, self-disclosure and interpersonal dependency together accounted for 17.4 percent of the variance in loneliness. Implications for nursing practice are discussed with particular emphasis on potential strategies for preventing loneliness.