Effects of Prazosin and Indomethacin on the α-Adrenergic Stimulation of Rabbit Myometrium
作者:
Vanessa A. Barss,
Mark Phillippe,
Laurence Valles,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1988)
卷期:
Volume 25,
issue 1
页码: 42-46
ISSN:0378-7346
年代: 1988
DOI:10.1159/000293744
出版商: S. Karger AG
关键词: Catecholamines;Prostaglandin;F2α;Norepinephrine
数据来源: Karger
摘要:
The effect of norepinephrine (NE) stimulation of near-term pregnant rabbit myometrium was studied by comparing cumulative dose-response curves for NE and NE with prazosin or indomethacin. Prazosin blocked the stimulatory effects of NE. Indomethacin pretreatment resulted in attenuation, but not suppression of contractile activity. Myometrial activity was associated with a progressive increase in the synthesis of prostaglandin (PG) F2α·Our observations suggest that α-adrenergic agonists have some myometrial stimulating effect independent of PG production.
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