Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants: relationship to hypoxic‐ischemic encephalopathy
作者:
Henrik Hagberg,
Eva Thornberg,
Mats Blennow,
Ingemar Kjellmer,
Hugo Lagercrantz,
Klara Thiringer,
Anders Hamberger,
Mats Sandberg,
期刊:
Acta Pædiatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 12
页码: 925-929
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12601.x
出版商: Blackwell Publishing Ltd
关键词: Asphyxia;brain;excitatory amino acids;hypoxia;ischemia;newborn
数据来源: WILEY
摘要:
Asphyxiated (n = 27) and control infants (n = 25) were subjected to spinal taps. Amino acids were measured with liquid chromatography and the degree of hypoxic‐ischemic cncephalopathy was determined in each case. In asphyxiated infants, the concentrations of aspartate and glutamate were 286% and 387% (p0.01 andp0.05) of the control values. respectively. The Cerebrospinal fluid aspartate levels were significantly (p0.05) higher in the group with severe (3.4 μmol/l) compared with the group with mild hypoxic‐ischemic encephalopathy (1.0 μmol/l). Glutamate was also higher in the group with severe (12.3 μmol/l) than in the groups with mild (2.7 μmol/l) or moderate (3.2 μmol/l) hypoxic‐ischemic enccphalopathy (p0.05). High concentrations of excitatory amino acids were present in the CSF of asphyxiated infants which may exert excitotox
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