Facilitation through Hyperventilation of Therapeutic Effect of Pyrithioxin in Cerebral Infarct Patients
作者:
E. Stoica,
O. Enulescu,
M. Gheorghiu,
期刊:
European Neurology
(Karger Available online 1975)
卷期:
Volume 13,
issue 4
页码: 285-303
ISSN:0014-3022
年代: 1975
DOI:10.1159/000114684
出版商: S. Karger AG
关键词: Cerebral infarction;Pyrithioxin;Hyperventilation;Hemiplegia;Motor recovery;Catecholamine release;Blood-brain barrier
数据来源: Karger
摘要:
A method of treatment consisting in administration of a neurodynamic drug, pyrithioxin, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with hemiplegia. The combination was superior to pyrithioxin alone for the motor recovery of these patients. In some cases, it induced immediately a partial restoration of motility. The combination constantly brought about an increase in urinary excretion of norepinephrine and vanilmandelic acid, which failed to occur after pyrithioxin or HV alone. HV appears to facilitate the neural effects of the drug by promoting its transfer into the CNS.
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