Apolipoprotein E and atherosclerosis
作者:
Linda Curtiss,
William Boisvert,
期刊:
Current Opinion in Lipidology
(OVID Available online 2000)
卷期:
Volume 11,
issue 3
页码: 243-251
ISSN:0957-9672
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease.
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