Epidermal Growth Factor Receptor Expression in Gynecological Malignancies
作者:
F. Battaglia,
G. Scambia,
Benedetti Panici,
G. Baiocchi,
L. Perrone,
S. Iacobelli,
S. Mancuso,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1989)
卷期:
Volume 27,
issue 1
页码: 42-44
ISSN:0378-7346
年代: 1989
DOI:10.1159/000293614
出版商: S. Karger AG
关键词: Epidermal growth factor receptors;Ovarian tumors;Carcinoma of the cervix;Endometrial cancer;Vulvar carcinoma;Uterine sarcoma
数据来源: Karger
摘要:
Epidermal growth factor receptor (IEGF-R) levels were analyzed in 72 gynecological tumor specimens. Measurable EGR-R levels were found in a significant percentage of ovarian and uterine tumors. Moreover, all vulvar epidermoid carcinomas and uterine sarcomas analyzed were EGF-R positive. In all tumor types examined, scattered EGF-R levels were observed. Higher EGF-R levels were found in metastatic than in primary ovarian tumors. Moreover, EGF-R were found to be more expressed in less differentiated than in well-moderately differentiated endometrial tumors. Our results suggest a role of EGF or EGF-like substances in regulating the growth of gynecological malignancies, and indicate EGF-R expression as a possible prognostic factor.
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