Urinary albumin excretion rate and puberty in non‐diabetic children and adolescents
作者:
H‐J Bangstad,
K Dahl‐Jørgensen,
P Kjæxsgaard,
K Mevold,
KF Hanssen,
期刊:
Acta Pædiatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 11
页码: 857-862
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12580.x
出版商: Blackwell Publishing Ltd
关键词: Microalhuminuria;non‐diabetics. puberty;reference value;screening
数据来源: WILEY
摘要:
Slightly elevated urinary albumin excretion rate (microalbuminuria) is a marker of early diabetic nephropathy, but it is unclear if the established definition of microalbuminuria (20–200 μg/min) is correct for children and adolescents. We investigated the albumin excretion rate, albumin/creatinine ratio and urinary albumin concentration in 150 healthy schoolchildren and adolescents to (a) obtain a reference value for albumin excretion rate, (b) relate albumin excretion to pubertal stages and (c) evaluate albumin/creatinine ratio and morning albumin concentration as screening methods for elevatcd albumin excretion rate. Albumin concentration was measured by immunoturbidimetry in timed overnight urine samples. The albumin excretion showed a skewed distribution (geometric mean 3.2 μg/min, 95 percentile 15.1 μg/min). In girls, a peak in the albumin excretion rate was found at the pubertal stage 4 (Tanner) and in boys at stage 5. Albumin/creatinine ratio of 2.5 mg/mmol as a scrccning level for elevatcd albumin cxcrction (15 μg/min) showed a high positivc (0.88) and negative (0.99) predictive
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