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Detection of mononuclear cells expressing hepatitis B virus in peripheral blood from HBsAg positive and negative patients by in situ hybridisation

 

作者: M. Hadchouel,   C. Pasquinelli,   J. G. Fournier,   R. N. Hugon,   J. Scotto,   O. Bernard,   C. Brechot,  

 

期刊: Journal of Medical Virology  （WILEY Available online 1988）
卷期: Volume 24, issue 1  

页码: 27-32

 

ISSN:0146-6615

 

年代: 1988

 

DOI:10.1002/jmv.1890240105

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: HBV;mononuclear blood cells;RNA;in situ hybridisation

 

数据来源: WILEY

 

摘要:

AbstractIn situ hybridisation was used to detect RNA of Hepatitis B virus (HBV) in peripheral mononuclear blood cells. Presence of HBV‐RNA was detected in 10/17 HBsAg positive HBeAg positive patients, in 8/18 HBsAg positive HBeAg negative patients, in 1/3 anti‐HBs positive subjects. Four control subjects were negative. The frequency of labelled cells varied from 1 to 10% of mononuclear cells. These results indicate that the DNA detected so far in mononuclear blood cells may be transcriptionally act

 

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