Autoradiographic Studies on the Influence of Gestagens on Oestrogen-Induced Incorporation of3H-Uridine and3H-Thymidine into Nucleic Acids of the Rat Uterus
作者:
G. Trams,
J. Raese,
H. Maass,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1973)
卷期:
Volume 4,
issue 3-4
页码: 155-164
ISSN:0378-7346
年代: 1973
DOI:10.1159/000301719
出版商: S. Karger AG
关键词: Progesterone;Rat uterus;RNA synthesis;3H-thymidine index
数据来源: Karger
摘要:
A single dose of oestradiol stimulates proliferative activity in the endometrium of castrated rats. This was tested autoradiographically by measuring 3H-thymidine and 3H-uridine incorporation and by determining the mitotic index. Administration of gestagens simultaneously or at different time intervals after oestradiol treatment (early G1 or early S phase) resulted in an inhibition of 3H-thymidine uptake which was greatest with simultaneous application of the two steroids. With regard to 3H-uridine incorporation into the different uterine cell types, progesterone produced a significant inhibition of RNA synthesis in all three cell types most pronounced in the myometrium. The role of these effects is discussed with regard to the growth-inhibiting effect of gestagens in human endometrial carcinoma.
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